Gelucire« 48/16

Macrogol stearate Polyoxyl stearate (Type I)

GattefossÚ

A non-ionic water soluble surfactant composed of well-characterised polyethylene glycol (PEG) esters and free PEG.

Key Features

  • A non-ionic water soluble surfactant composed of well-characterised polyethylene glycol (PEG) esters and free PEG.
  • Able to form a micellar solution contact with aqueous media.
  • Solubilizer and wetting agent: surfactive power improves the solubility and wettability of active pharmaceutical ingredients in vitro and in vivo.
  • Oral bioavailability enhancement reported to be associated with improved drug dispersion and solubilization and possible inhibition of efflux transporter (P-gP).

  • Physical Form

    • Pellets

    Hydrophilic-Lipophilic Balance (HLB)

    • 12

    Field of use

    • Human pharmaceutical products, veterinary pharmaceutical products including food producing animals

    Administration Route

    • Oral

    Formulation techniques and dosage forms

    • Suitable primarily for hard gelatin capsule molding.
    • Can be used in soft gelatin capsules.
    • Suitable for use in melt processing techniques: melt granulation (thermoplastic pelletization) and melt extrusion techniques for capsule filling, tabletting, sachets etc
This product belongs to