Gelucire® 44/14

Lauroyl macrogol / polyoxyl 32 glycerides / Lauroyl Polyoxylglycerides

Gattefossé

A non-ionic water dispersible surfactant composed of well-characterized PEG-esters, a small glyceride fraction and free PEG.

Key Features

  • A non-ionic water dispersible surfactant composed of well-characterized PEG-esters, a small glyceride fraction and free PEG.
  • Able to self-emulsify on contact with aqueous media forming a fine dispersion ie. microemulsion (SMEDDS).
  • Solubilizer and wetting agent: surfactive power improves the solubility and wettability of active pharmaceutical ingredients in vitro and in vivo.
  • Bioavailability enhancer: increased bioavailability could be associated with inhibition of the enterocytic efflux transporter (known as P-gP inhibition).
  • Good thermoplasticity for use as a binder in melt processes, associated with rapid formation of stable crystalline phase.

Safety of use is supported by extensive toxicological evaluations and precedence of use in approved pharmaceutical products.


Physical Form

  • Semi-solid block

Hydrophilic-Lipophilic Balance (HLB)

  • 11

Field of use

  • Human pharmaceutical products, veterinary products excluding food producing animals (EU).

Administration Route

  • Oral

Formulation techniques and dosage forms

  • Suitable for use in melt processing techniques: melt granulation (thermoplastic pelletization) and melt extrusion techniques for capsule filling, tabletting, sachets etc.
  • Suitable for hard gelatin capsule molding.
  • Suitable for adsorption onto neutral carrier powders for use in tablets, capsule filling and sachets.
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