Labrafil® M1944CS

Oleoyl macrogol-6 / polyoxyl-6 glycerides

Gattefossé

A water dispersible surfactant composed of well-characterized PEG-esters and a glyceride fraction. Able to self-emulsify on contact with aqueous media forming a coarse dispersion ie. emulsion (SEDDS).

Key Features

Oral

  • A water dispersible surfactant composed of well-characterized PEG-esters and a glyceride fraction.
  • Able to self-emulsify on contact with aqueous media forming a coarse dispersion ie. emulsion (SEDDS).
  • Good miscibility with Labrasol® and Gelucire® 44/14 to form a fine dispersion ie. microemulsion (SMEDDS).
  • Solubilizer: surfactive power improves the solubility of active pharmaceutical ingredients in vitro and in vivo.
  • Bioavailability enhancer: increased oral bioavailability is potentially associated with the long chain tryglyceride composition and selective absorption of highly lipophilic APIs by the lymphatic transport system.

Topical

  • A water-in-oil surfactant / solubilizer associated with enhanced drug penetration.
  • Used as a co-emulsifier in association with Tefose® 63 to form elegant creams.

Safety is supported by substantial toxicological data and precedence of use in approved pharmaceutical products.


Physical Form

  • liquid

Hydrophilic-Lipophilic Balance (HLB)

  • 9

Field of use

  • Human pharmaceutical products, veterinary products excluding food producing animals (EU)

Administration Route

  • Oral
  • Topical

Formulation techniques and dosage forms

  • Suitable for hard gelatin and soft gelatin capsules.
  • Suitable for adsorption onto neutral carrier powders for use in tablets, capsule filling and sachets.
  • Use in topical ointments, microemulsions and emulsions.
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