Plurol® Oleique CC 497

Polyglyceryl-3 dioleate / oleate

Gattefossé

A water insoluble surfactant for use in self emulsifying systems to obtain a coarse dispersion ie. emulsion (SEDDS) or a fine dispersion ie. microemulsion (SMEDDS).

Key Features

Oral

  • A water insoluble surfactant for use in self emulsifying systems to obtain a coarse dispersion ie. emulsion (SEDDS) or a fine dispersion ie. microemulsion (SMEDDS).
  • Bioavailability enhancer: increased oral bioavailability is potentially associated with the long chain fatty acids present in its composition and selective absorption of highly lipophilic active pharmaceutical ingredients by the lymphatic transport system.

Topical

  • A water-in-oil surfactant / solubilizer associated with enhanced drug penetration.

Safety is supported by substantial toxicological data and precedence of use in approved pharmaceutical products.


Physical Form

  • liquid

Hydrophilic-Lipophilic Balance (HLB)

  • 3

Field of use

  • Human pharmaceutical products, veterinary products including food producing animals

Administration Route

  • Oral
  • Topical

Formulation techniques and dosage forms

  • Suitable for hard gelatin and soft gelatin capsules.
  • Suitable for adsorption onto neutral carrier powders for use in tablets, capsule filling and sachets.
  • Use in topical ointments, microemulsions and emulsions.
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